在肝炎感染中,HERV-K10作为免疫调节的媒介
Salih Özer1,2, Romano Strobelt1,2, Anna D Kosinska1,2
1Institute of Virology, Helmholtz Munich, Munich, Germany.
Frontiers in immunology
|October 3, 2025
概括
人体内源逆转录病毒 (HERVs),如HERV-K10,在肝炎感染中被上调,影响免疫反应. 在HERV-K10中使用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 人体内源逆转录病毒 (HERVs) 占人类基因组的8%左右.
- HERVs的重新激活与包括癌症和自身免疫性疾病在内的疾病有关.
- 在免疫调节和病毒感染方面,HERV-K10对其潜在作用特别感兴趣.
研究的目的:
- 为了研究在肝炎病毒感染中HERV-K10的表达.
- 确定HERV-K10对宿主基因表达和免疫反应的影响.
- 探索 HERV-K10 MAG1 域的免疫调节作用.
主要方法:
- 在型肝炎病毒 (HCV) 患者的外周血液单核细胞 (PBMC) 中分析HERV-K10.
- 在B型肝炎病毒 (HBV) 感染的肝细胞模型 (HepG2-NTCP,初级肝细胞) 中检查HERV-K10.
- 在小鼠和慢性乙型肝炎患者中对HBV感染细胞的RNA测序和免疫学测定.
主要成果:
- 在感染HBV的HepG2-NTCP细胞和感染HCV的PBMC中观察到HERV-K10的显著上调.
- 激活HERV-K10是针对肝炎感染的特异性,与其他病毒感染或抑制剂没有观察到.
- 用HERV-K10 MAG1接种疫苗诱导了小鼠的T细胞反应和抗体.
- 慢性乙型肝炎患者对MAG1表现出免疫反应,IL-6和IL-1β水平升高.
结论:
- 在病毒性肝炎感染期间,HERV-K10被上调.
- 在这些感染期间,HERV-K10,特别是其MAG1域,在免疫调节中发挥作用.
- HERV-K10可能会导致与病毒性肝炎相关的自身免疫性疾病的发病.
更多相关视频
10:12Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
9.1K
10:37Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
3.4K
相关概念视频
Immune Response Against Viral Pathogens
1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K
Cytotoxic T Cells-mediated Immune Response
6.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.5K
Regulation of Hematopoietic Stem Cells
4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K
Cell-mediated Immune Responses
83.5K
Overview
83.5K
