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自闭症白质微观结构的广泛变化:多层次的元分析

Christy D Yoon¹, Andrew L Alexander^1,2,3, Brittany G Travers^1,4

¹Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.

Research square

|October 3, 2025

概括

自闭症谱系障碍 (ASD) 与白质微观结构的改变有关,ASD患者在关键脑道中表现出较低的分数异构性 (FA) 和较高的平均扩散性 (MD). 这些发现突出了ASD中复杂的神经生物学差异.

科学领域:

神经成像是一种神经成像.
神经发育障碍神经发育障碍
大脑的连接性大脑的连接性

背景情况:

破坏大脑连接是自闭症谱系障碍 (ASD) 的核心特征.
扩散张力成像 (DTI) 对于研究ASD白质微观结构至关重要.
在患有ASD的人群中,DTI研究经常显示分数异构性 (FA) 降低,平均扩散性 (MD) 增加.

研究的目的:

用FA和MD测量方法对ASD中白质微观结构的变化进行元分析.
评估参与者特征和横向性如何调节这些差异.
为了评估11个白质通道的变化.

主要方法:

具有多层结构的多变量随机效应元分析.
包括来自59项研究的680个效果大小 (N_ASD = 1,750,N_TD = 1,484).
分析了2至50岁个体的数据.

主要成果:

显著的中度效果大小减少FA在8个白质通道的个体与ASD.
显著的中等到大效果大小增加了MD在六个白质通道的个体与ASD.
主持人表示,特征和特征特有的效应.

结论:

在自闭症中白质变化是复杂的和多维的.
这些发现强调了ASD中大脑微观结构的神经生物学差异.
需要进一步的研究来探索性别和寿命之间的差异.

关键词:

在 DTI 中,DTI 是指DTI.自闭症自闭症是什么这是一个元分析.微观结构的微观结构定量的MRI是指MRI的数量.白质是白色物质的组成部分.

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