Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammatory Response01:28

Inflammatory Response

16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sex-specific associations of perioperative Resolvin D1 and D2 dynamics with postoperative atrial fibrillation in cardiac surgery: a secondary analysis of a prospective observational study.

European heart journal open·2026
Same author

Association of IgG N-Glycans With Adverse Outcomes in CKD.

Kidney international reports·2026
Same author

Postoperative c-reactive protein resolution patterns in patients with and without postoperative atrial fibrillation after cardiac surgery.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.

Research square·2026
Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026
Same author

Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026

相关实验视频

Updated: Jan 16, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

通过使用基于AI的网络集成网络的多omics通过免疫和炎症解决途径.

Azam Yazdani1, Anika Mijakovac2, Franco Giulianini3

  • 1Harvard Medical School.

Research square
|October 3, 2025
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种基于人工智能的网络集成方法,以解开复杂的多omics数据,揭示了脂质介质和糖化在免疫调节和炎症解决中的生物联系.

更多相关视频

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.6K

相关实验视频

Last Updated: Jan 16, 2026

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.6K

科学领域:

  • 免疫学 免疫学 免疫学
  • 系统生物学 系统生物学
  • 基因组学就是基因组学.
  • 代谢学 代谢学 代谢学
  • 格莱科米克斯 (Glycomics) 是一个有趣的药物.

背景情况:

  • 由于数据异质性,高维度和缺失的值,多主题数据集成具有挑战性.
  • 了解免疫调节和炎症解决需要整合不同的分子配置文件.
  • 现有的方法很难有效地建模复杂的经济间关系.

研究的目的:

  • 提出和验证基于人工智能的网络集成方法,用于多omics数据.
  • 调查免疫球蛋白GN甘氨酸 (甘氨酸) 和免疫和炎症通路中的专业的亲溶解脂质介质 (SPM) 之间的关系.
  • 确定影响免疫调节的分子因果网络和桥梁分子.

主要方法:

  • 跨截面的多组学研究 (遗传,糖组,脂组数据).
  • 以人工智能为基础的网络集成,用于建模互联互通连接.
  • 双向关联分析和条件分析.
  • 主要组件分析 (PCA) 用于多基因因子导出.
  • 颗粒度定向环形图 (G-DAG) 算法用于孟德尔随机化.

主要成果:

  • 基于人工智能的网络集成成功模拟了奥米克层的复杂生物系统影响.
  • 确定了10个显著的甘-SPM关联,其中两个桥梁分子 (5-HEPE SPM和GP21甘) 调解这些链接.
  • 发现5-HEPE和GP21都处于多基因控制之下,分别有不同的接收器和广播器角色.
  • 揭示了SPM脂管学变异和糖化变化之间的生物联系.

结论:

  • 基于人工智能的网络集成方法从杂的多omics数据中提供可解释和生物学上有意义的见解.
  • 研究结果表明,脂质调解剂与甘氨酸介导的免疫调节和炎症解决之间存在新的联系.
  • 这项研究强调了整合遗传,糖质和脂质组数据的实用性,以揭示复杂的生物途径.