相关实验视频

Updated: Jan 16, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

德斯弗隆安全性审查:一项药监测研究检测了FAERS数据中的潜在安全信号

Wei Wei¹, Liang Chen², Xiaomei Ying³

¹Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.

Journal of pain research

|October 3, 2025

概括

这项研究发现了desflurane的严重安全问题,包括心肌梗塞和过敏性休克. 与急性呼吸窘迫综合征和传播性血管内凝血的新相关性突出显示了持续药物监测的必要性.

科学领域:

麻醉学麻醉学
药物监督药物监督药物监督
药品安全药品安全

背景情况:

德斯兰是一种常用的挥发性麻醉剂.
为了优化德斯兰的安全性,全面的药物监测是必不可少的.
现有的数据缺乏对德斯兰相关不良事件的详细分析.

研究的目的:

分析和分类与desflurane相关的不良事件 (AE).
通过FAERS数据库评估潜在的安全信号.
为了提高对德斯兰临床安全性的理解.

主要方法:

从FDA不良事件报告系统 (FAERS) 数据库 (2004Q1-2025Q1) 中对德斯弗报告的分析.
使用"监管活动医学词典" (MedDRA) 进行病例分类.
应用了四种不成比例性分析:ROR,PRR,BCPNN和MGPS.

主要成果:

鉴定了1,191个与德斯弗相关的副作用,其中最常见的是心肌梗塞 (n=39).
重要的安全信号包括过敏性休克 (n=23),支气管 (n=22) 和恶性热升 (n=20,25%的死亡率).
新发现的与急性呼吸困难综合征 (ARDS) 和传播性血管内凝血 (DIC) 的相关性已被记录.

结论:

德斯兰显示出显著的安全信号,包括心血管,过敏和呼吸道并发症.
对于接受德斯弗兰的患者,可能需要加强外科手术期间的监测.
持续的营销后监测对于检测罕见但严重的安全信号至关重要.

关键词:

DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC DIC 公平的人是公平的.过敏性休克是一种过敏性休克.德斯弗鲁兰是什么意思德斯弗鲁兰是什么意思感觉感觉感觉感觉药物监督和药物监督

更多相关视频

Administration of Volatile Anesthetics to Zebrafish Larvae for Behavioral Observation

Administration of Volatile Anesthetics to Zebrafish Larvae for Behavioral Observation

Published on: June 6, 2025

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

相关概念视频

Pharmacovigilance

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

Inhalational Anesthetics: Overview

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...