用PD-1抑制剂治疗高级NSCLC的老年患者因特定原因死亡率相关的因素:美国基于人口的队列研究
Yeijin Kim1,2,3, Yan Liu4, Hae Sun Suh1,3,5
1College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Cancer control : journal of the Moffitt Cancer Center
|October 3, 2025
概括
在接受PD-1抑制剂治疗的晚期非小细胞肺癌 (NSCLC) 的老年人中,心血管疾病 (CVD) 死亡率与充血性心力衰竭和社会经济因素有关,而不是PD-1抑制剂类型.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 免疫检查点抑制剂,特别是PD-1抑制剂 (PD-1i),改善了晚期非小细胞肺癌 (NSCLC) 的治疗结果.
- 然而,接受PD-1i的老年人死亡原因尚不清楚.
- 这项研究调查了这一群体因特定原因死亡率的预测因素.
研究的目的:
- 估计与PD-1i治疗的晚期NSCLC的老年人因特定原因死亡率.
- 确定癌症,心血管疾病 (CVD) 和其他原因死亡率的预测因素.
主要方法:
- 使用2014-2019年SEER-Medicare链接数据库进行回顾性队列研究.
- 包括65岁以上的晚期NSCLC患者,接受尼沃卢马布或潘布罗利祖马布治疗.
- 竞争风险分析 (细灰模型) 用于评估死亡率预测因素.
主要成果:
- 在5076名患者中,NSCLC是主要的死亡原因 (85.34%),而心血管疾病占2.80%.
- 充血性心力衰竭 (CHF) 和医疗补助双重资格预测了心血管疾病死亡率的增加.
- 与nivolumab相比, pembrolizumab与较低的NSCLC死亡风险有关.
结论:
- 综合性心脏瘤护理和解决社会经济差距对于PD-1i中高级NSCLC的老年人至关重要.
- 研究结果表明,慢性心血管疾病和社会经济地位显著影响心血管疾病死亡风险.
- 需要进一步的研究,考虑到数据的局限性,例如缺乏生物标志物信息.
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