一个生物生态模型,用于早期查发育协调障碍
Xiaotian Dai1,2, Tai Ren3, Gareth Williams4
1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Developmental medicine and child neurology
|October 3, 2025
概括
这项研究开发了一种生物生态模型,使用电子健康记录来选幼儿发育协调障碍 (DCD). 该模型对早期检测和干预有希望,特别是在学龄前儿童中.
科学领域:
- 儿科健康 儿科健康
- 发育儿科 发育儿科
- 公共卫生信息学 公共卫生信息学
背景情况:
- 发育协调障碍 (DCD) 影响儿童的运动技能,影响日常活动.
- 早期识别DCD对于及时干预和改善结果至关重要.
- 现有的查方法可能无法充分利用易于获得的电子健康记录 (EHR) 数据.
研究的目的:
- 开发和验证用于早期DCD查的生物生态模型.
- 使用来自EHR的孕产妇和环境风险因素进行预测.
- 改善在5岁以下儿童中早期检测DCD.
主要方法:
- 一项涉及中国150,948名学龄前儿童的前性研究.
- 后勤回归和随机森林算法集成了围产期和社会人口统计预测因素.
- 在分割数据集的内部验证和1359名儿童 (3-10岁) 的外部验证证实了DCD.
主要成果:
- 对于3-5岁的儿童,该模型的AUC为0.70,灵敏度为71.43%,准确度为77.61%,特异性为78.00%.
- 对于6-10岁的儿童,表现中等,AUC为0.58,灵敏度为54.88%,精度为61.50%,特异性为62.28%.
结论:
- 开发的生物生态模型是一种可扩展,具有成本效益的工具,用于使用EHR数据早期识别DCD.
- 该模型在幼儿时期表现良好,在老年儿童中表现适度,有助于长期风险预测.
- 这种工具可以增强当前的查系统,使得DCD的早期分拣和干预成为可能.
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