慢性病G3-5在狼性炎中 - 患病率,进展和危险因素
Selene T Y Teoh1,2, Desmond Y H Yap1, Colin S O Tang1
1Division of Nephrology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR.
概括
慢性病 (CKD) 在10年内影响大约五分之一的狼性炎 (LN) 患者. 早期的EGFR和炎爆发预测CKD,而特定的治疗方法可以降低风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 关于狼性炎 (LN) 患者慢性病 (CKD) 发展的长期数据有限.
- 尽管治疗进展,但调查CKD进展和LN的风险因素至关重要.
研究的目的:
- 在中国患者中调查CKD的患病率和进展,这些患者有活检证明的狼性炎 (LN).
- 确定与CKD发展和LN患者不良结果相关的风险因素.
主要方法:
- 对183名在1981-2017年间被诊断患有活检证明的LN的中国患者进行了回顾性研究.
- 结核病G3-5定义为eGFR<60毫升/分钟/米2>3个月;使用多变量逻辑回归分析的风险因素.
主要成果:
- 在19.9年的时间里,34.4%的患者患有CKD G3-5型,9.8%的患者患有功能衰竭,14.2%的患者死亡.
- 高龄,功能障碍,高血压和炎发作与CKD G3-5.5相关.
- 一年后低EGFR和≥2次炎爆发预测CKD G3-5;mycophenolate和葡萄糖皮质激素治疗降低了风险.
结论:
- CKD G3-5在LN患者中很常见,在10年后影响到20%左右.
- 一年内eGFR<80毫升/分钟/1.73m2和≥2次炎发作是关键的危险因素.
- 持续的甲酸和葡萄糖皮质类药物治疗与降低CKD G3-5风险有关.
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