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动态对比度增强MRI上的纵向冲入斜率变化用于预测乳腺癌中新辅助化疗的反应

Yanbo Li¹, Jingbo Wang¹, Jinxia Guo²

¹Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.

European radiology

|October 3, 2025

概括

在新辅助化疗 (NAC) 期间洗进斜率 (WIS) 的变化可以预测乳腺癌患者的病理完整反应 (pCR). 动态对比增强型MRI (DCE-MRI) 衍生的WIS变化为治疗监测提供了可靠的成像生物标志物.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

预测乳腺癌中新辅助化疗 (NAC) 的病理完整反应 (pCR) 对治疗优化至关重要.
目前,缺乏标准化的成像生物标志物来预测NAC期间的PCR.

研究的目的:

评估通过动态对比增强MRI (DCE-MRI) 测量的洗入斜率 (WIS) 的变化是否可以预测接受NAC.乳腺癌患者的PCR.
评估WIS在NAC期间在不同时间点和分子亚型中变化的预测性能.

主要方法:

对162名接受NAC和手术的女性乳腺癌患者的回顾性分析.
进行了DCE-MRI治疗前,治疗后2和4个周期,以及NAC后.
计算了瘤WIS (ΔWIS) 的百分比变化,并使用AUC评估了pCR的预测性能.

主要成果:

在NAC期间,在所有评估时间点上,ΔWIS在预测PCR方面表现相似且强 (AUC从0.82到0.87).
达WIS的最佳值达到74.4%-86.0%之间的灵敏度和75.6%-80.7%之间的特异性.
4个周期后的 ΔWIS 显示了三阴性乳腺癌中pCR的优异预测性能 (AUC,0.96).

结论:

来自DCE-MRI的瘤WIS变化可以动态监测乳腺癌中新辅助化疗反应.
纵向WIS变化作为一个有价值的成像生物标志物,用于实时预测治疗反应,帮助个性化治疗决策.

关键词:

乳腺癌乳腺癌乳腺癌动态对比增强动态对比增强磁共振成像技术磁共振成像技术新辅助化学疗法新辅助化学疗法病理学的完整反应.

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Magnetic Resonance Imaging

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