在COVID-19发生三年后的功能和认知结果
Melanie Li1, Thomas Wisniewski2, Floyd Silva1
1Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Clinical neurology and neurosurgery
|October 3, 2025
概括
与对照组相比,长期COVID患者在感染后3年内报告了显著更多的神经精神症状. 然而,两组之间没有观察到功能或认知结果的差异.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 有限的数据存在于COVID-19后的长期功能和认知后续.
- 了解COVID-19后的结果对于患者管理和公共卫生至关重要.
研究的目的:
- 为了比较COVID-19感染后至少一年的患者的长期功能,认知和神经精神病学结果,与对照组进行比较.
- 评估一小组COVID-19患者的康复轨迹.
主要方法:
- 观察性队列研究比较COVID-19幸存者 (N=115) 与COVID-19负控人 (N=30).
- 评估功能状态 (mRS,巴特尔指数),认知功能 (t-MoCA) 和神经精神病症状.
- 使用多变量逻辑回归和配对样本进行分析的标志测试.
主要成果:
- COVID-19患者报告的神经精神病症症状显著增加 (76%对7%,aOR 15.0).
- 在对共变量进行调整后,修改的兰金度量表 (mRS) 没有显著差异,电话蒙特利尔认知评估 (t-MoCA) 和巴特尔分数也没有显著差异.
- 功能状态 (mRS) 在纵向子组 (p=0.004) 中随着时间的推移显著改善.
结论:
- 在COVID-19后的三年里,与对照组相比,神经精神病症状更为普遍.
- 在COVID-19幸存者和对照者之间没有发现功能或认知状态的长期显著差异.
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