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Updated: Jan 16, 2026

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
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使用人类iPSC衍生的心肌细胞对托尔萨多基因风险药物的双心脏毒性评估

Seul-Gi Lee1, Min Woo Kim1, Shinhye Park1

  • 1College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.

Biochemical and biophysical research communications
|October 3, 2025
PubMed
概括

这项研究使用人类诱导的多能干细胞 (hiPSCs) 来评估药物心脏毒性. 一项新的双重测定表明,低风险药物降低了收缩性,为药物安全提供了更好的预测查.

关键词:
契约性 契约性是指契约性.双心脏毒性评估方法的双心脏毒性评估方法.现场潜在的潜力 现场潜在的潜力人类iPSC衍生的心肌细胞.微电极阵列是一个微电极阵列.体致病风险药物药物 体致病风险药物

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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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