微生物组-转录组-组织学三位一体增强了多种癌症的生存风险分层
Binsheng He1, Yanyu Ma2, Kun Wang3
1First Clinical College, Changsha Medical University, Changsha 410219, PR China; Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, PR China.
这项研究介绍了HMTsurv,这是用于癌症存活率预测的多式联络深度学习模型. 通过整合组织病理学,转录学和微生物组数据,它可以提高多种癌症的预后准确性.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 准确的癌症预后对于治疗决策至关重要.
- 目前用于生存预测的深度学习模型使用单个数据类型,限制了洞察力.
- 整合各种数据 (组织病理学,转录学,微生物组) 可以提高癌症预后.
研究的目的:
- 开发和验证HMTsurv,用于癌症生存预测的多式联络深度学习框架.
- 评估整合数字遗传病理学,宿主转录组学和瘤相关微生物组特征的预后准确性.
- 识别泛癌生存生物标志物,了解生存的生物决定因素之间的相互作用.
主要方法:
- 开发了HMTsurv,这是一个多式模式的深度学习框架,集成了他的病理学,转录学和微生物组数据.
- 利用了来自结肠直肠,胃,肝细胞和乳腺癌队列的多omics数据集.
- 通过交叉验证,卡普兰-梅尔分析和日志等级测试验证模型性能.
主要成果:
- 与单一模式模型相比,HMTsurv显示出更高的预后准确性 (c指数:0.68-0.72).
- 该模型在所有癌症类型中实现了强大的风险分层 (日志数等级p < 0.001).
- 确定了14种泛癌存活生物标志物,包括MAGE家族基因,并阐明了关键的组织病理学,微生物和基因-微生物群相互作用.
结论:
- HMTsurv提供了一个可通用的多式联络架构,以改善癌症预后.
- 该框架强调了组织学,分子和生态因素在癌症生存中的相互作用.
- 这种方法为精密瘤学提供了一个临床可行的框架.
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