相关实验视频

Updated: Jan 16, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

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PARP1自动修改促进了忠实Okazaki片段处理,并限制了复制分叉速度

Jonas D Elsborg1, Sebastian H N Munk2, Alba Adelantado-Rubio2

  • 1Department of Cellular and Molecular Medicine, Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Molecular cell
|October 3, 2025
PubMed
概括

聚 ((ADP-ribose) 聚合酶抑制剂通过利用合成致死性来向癌症. 一项新的研究揭示了PARP1自动修饰,与其酶活性不同,对于DNA修复和防止复制应激至关重要.

关键词:
在ADP-ribosylation过程中.在DNA复制过程中,DNA复制有分叉.奥卡扎基岛的碎片这是一种PARP抑制剂.PARP1 的第一部分在PTM的PTM.自动修改自动修改电子转移解离的解离过程蛋白质组学资源资源 蛋白质组学资源复制压力是复制的压力.

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