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Updated: Jan 16, 2026

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有针对性的素化使得p53能够结合非正规位点

Alexandra Indeglia1, Andrea Valdespino2, Giulia Pantella3

  • 1Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA; Graduate Group in Biochemistry and Molecular Biophysics, the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Molecular cell
|October 3, 2025
PubMed
概括

基氨酸脱胺酶4 (PADI4) 酶使p53蛋白成为氨酸,改变其DNA结合. 这种修改将p53重定向到新的目标基因,影响细胞对压力的反应.

关键词:
在 ELF2 中, ELF2 是 ELF2 的代名词.在PADI4上,您可以使用PADI4.癌症 癌症 癌症 癌症 癌症素化是指素化.在 p53 里,p53 是一个 p53 的类型.

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