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相关概念视频

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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相关实验视频

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Induction and Analysis of Epithelial to Mesenchymal Transition
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表皮-介质细胞过渡

Cecilia Xi Zhang1, Ruby Yun-Ju Huang2, Guojun Sheng3

  • 1Biosyngen Pte Ltd, Tai Seng Exchange, Singapore 536671, Singapore.

Cell
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概括
此摘要是机器生成的。

表皮 - 介质过渡 (EMT) 是一种在发育和疾病中保存的过程. 了解EMT

关键词:
癌症表皮-介质细胞过渡纤维化消化过程启动时间甲类动物最少残留疾病发生的进展复发情况电阻治疗方法伤口愈合

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相关实验视频

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科学领域:

  • 发育生物学
  • 细胞生物学
  • 癌症生物学

背景情况:

  • 表皮 - 介质过渡 (EMT) 是甲基动物发育的一个基本过程.
  • EMT涉及细胞通过中间状态过渡,很少达到完全介质表型.
  • 这种可塑性对于像胃流动这样的形态遗传运动至关重要.

研究的目的:

  • 提供表皮-介质细胞转换 (EMT) 的深入研究.
  • 探索EMT在发育,组织修复和癌症等疾病中的作用.
  • 讨论最近的争议, 并确定新的治疗干预机会.

主要方法:

  • 关于EMT的文献审查和现有研究的综合.
  • 驱动EMT的分子机制的分析 (信号传递,代谢,表观遗传学).
  • 检查EMT在成年组织中的重新激活及其对病理学的影响.

主要成果:

  • 这是一个多阶段的,在进化过程中至关重要的过程.
  • 在成年组织中重新激活EMT,有助于修复,纤维化和癌症进展.
  • 瘤内的多个EMT状态会产生一个动态的生态系统,影响干部,侵袭和转移.

结论:

  • 在正常发育和疾病中发挥重要作用.
  • 了解EMT的复杂性为新的治疗策略提供了潜力.
  • 需要进一步探索EMT在组织修复和癌症中的功能.