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Updated: Jan 16, 2026

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在多发性硬化症中,Notch3会破坏调节性T细胞的稳定,从而驱动自身免疫性神经炎症

Mehdi Benamar1, Paola Contini2, Klaus Schmitz-Abe3

  • 1Division of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Immunity
|October 3, 2025
PubMed
概括

改变调节性T (Treg) 细胞表达Notch3驱动多发性硬化症 (MS) 中的神经炎症. 向Notch3稳定Treg细胞,预防疾病并促进中枢神经系统 (CNS) 中的免疫抑制.

关键词:
DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1 DLL1欧洲电子商务管理局 (EEAE)河马的路径 河马的路径这是一个NPY1RR.没有3ch3中枢神经系统中枢神经系统在 ex-Treg 细胞中.免疫耐受性 免疫耐受性多发性硬化症多发性硬化症监管T细胞的监管性T细胞

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