星球细胞介导的中央杏仁体微电路门在慢性疼痛中并发性焦虑症状
Gui-Ying Zan1, Song-Yu Yao2, Ying-Zhi Deng3
1CAS Key Laboratory of Receptor Research and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Shanghai 201203, China; Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Neuron
|October 3, 2025
概括
研究人员在中枢桃体 (CeA) 中发现了一个大脑电路,该电路将慢性疼痛与焦虑联系起来. 这一途径涉及特定的神经元和星球细胞,为与疼痛相关的焦虑提供了新的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 焦虑症 焦虑症 焦虑症
背景情况:
- 伴随性焦虑是慢性疼痛的一个重要方面,但其潜在的神经机制尚未完全理解.
- 中枢桃体 (CeA) 在处理疼痛和焦虑方面发挥着作用,但其参与疼痛相关焦虑的特定微电路仍然不清楚.
研究的目的:
- 阐明CeA内部的特定微电路和细胞类型,这些微电路和细胞类型调节了与慢性疼痛相关的焦虑.
- 确定在慢性疼痛状态期间控制神经元和CeA中的质细胞之间的相互作用的分子机制.
主要方法:
- 研究了一种微电路,涉及横向CeA (CeL) 投射到中间CeA (CeM) 的dynorphinergic神经元.
- 研究了卡帕阿片类受体 (KORs) 在CeM星球细胞和皮质otropin释放因子 (CRF) 受体2信号传递中的作用.
- 评估了对N-甲基-D-酸盐受体 (NMDAR) 激活和D-血清释放的影响.
- 利用行为测试来评估与疼痛相关的焦虑的调制.
主要成果:
- 发现了一个CeL-to-CeM微电路,其中诺芬激活CeM星质KORs,增强CeM神经元刺激性和关闭与疼痛相关的焦虑.
- 这种激活取决于皮质otropin释放因子受体2的信号传递,并涉及释放D-氨酸,一种神经递质.
- 证明CeA神经元和星细胞之间的KOR介导的通信双向调节慢性疼痛的焦虑效应.
结论:
- 在中枢杏仁体内发现了一种新的神经质微电路,它是疼痛相关焦虑的基础.
- 确定了一种特定的途径,涉及dynorphin,KORs,CRF受体2和D-serine作为与疼痛相关的焦虑的关键调节者.
- 这些发现表明,这种CeA微电路中的潜在治疗点可以用于治疗慢性疼痛患者的焦虑.
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