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Updated: Jan 16, 2026

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一个新的miRNA-TF-mRNA调节网络与骨质疏松症中细胞衰老相关

Xiang Zhang1, Na Xu1, Yanman Zhou2

  • 1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China.

Stem cell reports
|October 3, 2025
PubMed
概括

微RNA-22-3p通过向ESR1促进骨质疏松症,增加细胞衰老和脂肪分化. 在小鼠中抑制miR-22-3p改善了骨健康,这表明了骨质疏松症的新治疗点.

关键词:
细胞衰老 细胞衰老雌激素受体-1 雌激素受体-1人类骨髓中介细胞干细胞在 miR-22-3pp 中使用.骨质疏松症是一种骨质疏松症.

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