在临床实践中,跨学科管理贝兰他马布 (belantamab) - 马福多丁相关的眼睛毒性
Mattan Arazi1, Aya Wattad2, Hila Magen3
1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK.
The ocular surface
|October 3, 2025
概括
对多发性骨髓瘤的Belantamab mafodotin治疗经常导致角质瘤病,需要频繁的管理变化. 早期的眼科监测对于管理角膜毒性和保持视力至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 贝兰他马布 (Belantamab mafodotin) 是一种用于复发性/耐药性多发性髓瘤 (RRMM) 的抗体-药物结合物.
- 角膜毒性,包括四肢干细胞功能障碍和上皮损伤,是已知的副作用.
- 角质病症严重程度与治疗管理之间的关系需要进一步研究.
研究的目的:
- 检查RRMM患者接受贝兰他马布马福多丁治疗的角质病症严重程度和血液学治疗决策之间的关联.
- 确定严重角质病变的预测因素以及管理干预措施对其进展的影响.
- 根据角质病的分级来确定管理变化的最佳时机.
主要方法:
- 在2019年至2022年期间,对RRMM患者接受贝兰他马布 (belantamab mafodotin) 治疗的回顾性队列研究.
- 在每次治疗周期之前进行眼科检查和角膜病变和视力敏度 (KVA) 评分.
- 时间依赖的共变量分析,以评估KVA严重程度与管理决策 (剂量减少,假期,停止) 之间的关联.
主要成果:
- 92.68%的患者患有KVA角质炎,比临床试验中报告的发病率高.
- 较高的KVA等级与较早的管理变化有显著的关联 (HR 1.514,p=0.0270).
- 治疗假期导致KVA恶化 (+0.70级),而剂量减少改善KVA (-0.20级).
结论:
- 在接受贝兰他马布 (belantamab mafodotin) 的患者中,角膜病变很常见,往往需要修改治疗.
- 从1级KVA开始,密切的眼科监测是必不可少的.
- 积极的管理调整可以减轻RRMM患者与视力相关的发病率.
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