在受孕后的前1000天内限制糖分,以及长期呼吸系统健康:一个准实验性研究
Jiazhen Zheng1, Chuang Yang2, Zhen Zhou3
1Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, Guangdong, China.
The American journal of clinical nutrition
|October 3, 2025
概括
在生命的头1000天内限制早期的糖摄入量可以显著降低成人喘和COPD的风险. 这种饮食方法还可以改善肺功能,延迟疾病发作,促进终身呼吸系统健康.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 早期高糖消费可能会对终身呼吸系统健康产生负面影响.
- 早期暴露于糖对成年人呼吸系统疾病和肺功能的长期影响尚不清楚.
研究的目的:
- 调查在前1000天限制糖摄入量与成人呼吸道疾病 (喘,慢性肺炎,IPF) 之间的关联.
- 探索潜在的调解机制,包括糖尿病,高血压和出生体重.
- 评估对肺功能参数的影响,如FEV1,FVC和FEV1/FVC比率.
主要方法:
- 采用了基于英国糖分配给时期 (1951-1956) 的准实验性设计.
- 与英国生物库参与者进行比较,这些参与者暴露于早期糖限制的不同持续时间.
- 在英国长度老龄化研究和健康与退休研究中验证了结果.
主要成果:
- 早期糖限制与喘 (HR 0.75) 和慢性肺炎 (COPD) (HR 0.73) 的风险降低有关,其发病时间延迟.
- 分配的参与者表现出改善的肺功能:更高的FEV1% (6.0),FVC% (5.9) 和FEV1/FVC比率 (0.045).
- 糖尿病和高血压部分介导了保护作用,而出生体重的影响最小.
结论:
- 在关键的前1000天内限制糖摄入与更好的成年肺功能和更低的喘和COPD风险有关.
- 这些发现强调了当前饮食指南对于促进持续呼吸系统健康的重要性.
- 早期的营养对长期的呼吸系统结果起着至关重要的作用.
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