预装注射器和后视内注射内炎:一个网络的元分析
Brendan K Tao1, Jiwon Hwang2, Shihyun Park3
1Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Survey of ophthalmology
|October 3, 2025
概括
制造的预先填充注射器 (PFS) 和复合注射器与瓶子制剂相比,显著降低了注射后内炎 (PIE) 的风险. PFS显示PIE几率最低,包括培养阳性病例,这表明内治疗的安全性有所改善.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 注射后内炎 (PIE) 是内内注射后的一个严重风险.
- 注射器填充技术各不相同,可能会影响PIE率.
- 预填注射器 (PFS),复合注射器和试剂瓶制备 (VPS) 是常见的方法.
研究的目的:
- 为了比较不同的注射器制备方法对PIE的几率,用于静脉内抗VEGF治疗.
- 评估整体和培养阳性PIE的发生率.
主要方法:
- 进行了罕见事件的频率网络元分析.
- 包括20项观察性研究,共计3,746次PIE事件和超过4100万次注射.
- 专注于PIE发病率是主要结果的研究.
主要成果:
- PFS (OR:0.45) 和复合注射器 (OR:0.69) 的PIE几率明显低于VPS.
- 与复合注射器相比,PFS的PIE几率明显较低 (OR:0.65).
- 与VPS (OR:0.15) 和复合注射器 (OR:0.15) 相比,PFS显著减少了培养阳性的PIE.
结论:
- 预填注射器 (PFS) 显著降低了临床和培养阳性注射后内炎 (PIE) 的风险.
- 与复合注射器和传统的瓶装制剂 (VPS) 相比,PFS提供了一个更安全的替代方案.
- 需要进一步的研究才能充分理解混因素.
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