多界面微气泡控制了对协同性血管破坏/化疗治疗的顺序性空洞化
Tiandong Chen1, Chenyi Zhang1, Yanxiao Zhao1
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, PR China.
概括
工程设计的多接口微气泡 (DOX-MIMBs) 使用超声波进行协同瘤治疗. 这种新的方法结合了瘤血管结构的机械破坏和增强的化疗,实现了显著的瘤减少.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 微气泡是用于超声波成像,药物输送和瘤切除的多功能超神论平台.
- 传统的微气泡在持续的声学活动和药物透方面存在局限性.
研究的目的:
- 为协同瘤治疗设计多接口微气泡 (DOX-MIMBs),具有增强的声学特性.
- 调查DOX-MIMBs在结合机械干扰和化疗的疗效,以精确治疗瘤.
主要方法:
- 通过防水性半孔性二氧化纳米粒子 (hMSNs) 的界面自组装来制造DOX-MIMB.
- 使用低强度超声波 (<3W/cm2) 诱导能量级别的化和连续的泡生成.
- 在临床前瘤模型中评估声学机械扰动和DOX输送的协同效应.
主要成果:
- 与传统的微气泡相比,DOX-MIMB显示了持续的声学活动和长时间的洞穴持续时间.
- 连续的泡腔化诱导了选择性血管破坏,并增强了DOX透到瘤中.
- 在细胞癌模型中通过联合机械药物治疗实现了90%的瘤体积减少.
结论:
- DOX-MIMBs代表了从系统性药物输送到局部机械化学瘤抑制的范式转变.
- 这种新型的输送系统通过整合机械干扰和化疗来提供精确瘤治疗的强大策略.
- 开发的DOX-MIMBs平台在推进癌症治疗方式方面具有重大潜力.
更多相关视频
08:24Introduction to the Ultrasound Targeted Microbubble Destruction Technique
Published on: June 12, 2011
16.0K
11:14A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
Published on: January 10, 2017
12.2K
相关概念视频
01:16Clot Retraction and Fibrinolysis
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
01:17Autoregulation of Blood Flow
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
01:26Mitral Stenosis III: Medical Management
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...