Tomomi Takahashi1, Takashi Nonaka2, Reiko Ohtani2

  • 1Department of Physics, Tokyo Metropolitan University, 1-1 Minami-osawa, Hachiouji-shi, Tokyo 192-0397, Japan.

Neuroscience research
|October 3, 2025
PubMed
概括

这就是阿尔茨海默病的原因.

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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