在使用大麻的人群中,揭示大麻暗示反应的性别差异
A M Kaag1, J Cousijn2, E Kroon2
1Departement of Clinical Neuropsychology, Vrije Universiteit Amsterdam, the Netherlands; Institute for Brain and Behavior Amsterdam (IBBA), Amsterdam, the Netherlands; Amsterdam Institute for Addiction Research, Amsterdam, the Netherlands.
Progress in neuro-psychopharmacology & biological psychiatry
|October 3, 2025
概括
大麻使用障碍 (CUD) 显示了大脑对线索反应的性别差异. 与男性不同,女性大麻使用者表现出的神经反应能力,这凸显了需要针对性别的CUD研究和治疗的需要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 大麻使用障碍 (CUD) 在流行和进展方面表现出显著的性别差异.
- 患有CUD的女性更快地从使用到障碍过渡,并且经常报告更严重的精神症状.
- 关于CUD中性别差异背后的神经机制的研究有限.
研究的目的:
- 调查大麻使用者和对照者在实验期间的神经暗示反应和渴望变化的性别依赖差异.
- 探索神经反应,渴望和大麻使用特征之间的特定性别关联.
主要方法:
- 功能性MRI (fMRI) 用于评估66名常规大麻使用者和71名对照者的神经暗示对大麻相关图像的反应.
- 渴望被测量使用大麻渴望问卷之前和之后的fMRI会议.
- 会议诱导的渴望被计算为从会议开始到会议结束的渴望得分的变化.
主要成果:
- 与男性相比,女性大麻使用者表现出与男性相比,右侧insula和putamen中的神经暗示反应减弱,在对照组中观察到的反向模式.
- 仅在女性中,会话诱导的缓解和奖励渴望与右上额头,小脑和前中心的暗示反应性正相关.
- 大麻使用的严重程度与女性的前中枢回环中的暗示反应性有关.
结论:
- 研究结果揭示了神经反应,渴望和CUD中大麻使用严重程度之间的复杂的性别相关相互作用.
- 这些结果强调了针对性别的研究和干预措施的关键需求,以解决CUD.
- 了解这些特定于性别的神经通路对于开发有效的CUD治疗至关重要.
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