使用PET量化心肌血流量:当前状态,临床应用和未来方向
Shekhar Vohra1, Sakul Sakul1, Vikram Agarwal1
1Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Progress in cardiovascular diseases
|October 3, 2025
概括
阳位子发射断层扫描 (PET) 精确量化心肌血流量 (MBF) 和流量储备 (MFR),与旧方法相比,提供了更好的诊断和预后见解. 这种先进的成像对于个性化的心血管护理至关重要.
科学领域:
- 心血管成像 - 心血管成像
- 核心脏病学 核心脏病学
- 生理学评估是指对身体的生理学评估.
背景情况:
- 单光子发射计算断层扫描 (SPECT) 可以低估冠状动脉疾病的严重程度.
- 定子发射断层扫描 (PET) 允许绝对量化心肌血流量 (MBF) 和心肌流量储备 (MFR).
研究的目的:
- 审查PET在MBF和MFR量化中的日益扩大的临床影响和不断变化的作用.
- 突出PET在各种心血管疾病中的诊断和预后价值.
主要方法:
- 对心肌动脉血液流量和储量的PET成像现有文献的综述.
- 讨论PET追踪剂和分析技术 (如AI,全身PET) 的进展.
主要成果:
- 来自PET的MBF和MFR具有显著的诊断和预后价值.
- 缺陷的流量储备预测了不良结果,无论 perfusion 缺陷如何.
- 新的标记剂和技术有望得到更广泛的临床采用和提高效率.
结论:
- 基于PET的流量量化正在成为精密心血管医学的组成部分.
- 指南建议在应力PET中进行常规流量量化,尽管接入和标准化挑战仍然存在.
- 需要进一步的以结果为导向的试验来巩固PET的作用.
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