系统性硬化和局部性硬化 (形状) 是一个常见的疾病谱的一部分吗? 对它们的共存进行系统审查
Carolina De Rosa1, Giorgia Di Marco1, Vanessa Bottino1
1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Dermatology Clinic, IRCCS San Raffaele Hospital, Milan, Italy.
Clinics in dermatology
|October 3, 2025
概括
系统性硬化症 (SSc) 和局部性硬化症 (LoS,morphea) 可以共存,这表明共享的自身免疫和纤维化的途径. 监测LoS患者的SSc进展至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 硬化症包括全身性硬化症 (SSc) 和局部性硬化症 (LoS,morphea).
- SSc影响内部器官,而LoS通常限于皮肤.
- SSc和LoS的共存表明了重叠的特征和潜在的共享机制.
研究的目的:
- 为了研究SSc和LoS (morphea) 的共存和关系.
- 在患有并存疾病的患者中确定常见的临床特征和自身抗体概况.
- 了解时间关系和潜在的共享病原体.
主要方法:
- 对23项涉及57名SSc和LoS (形态) 患者的研究进行了综述.
- 对患者人口统计学,临床亚型,全身表现和自身抗体流行率的分析.
- 检查疾病发病顺序和潜伏期.
主要成果:
- 大多数患者是女性 (84%),平均发病年龄为44岁.
- 最常见的是有限的皮肤SSc和结节形态. 雷诺特现象 (63%) 和硬质结节症 (53%) 是常见的.
- 在47%的病例中,SSc先于LoS,26%的病例先于LoS,26%的病例同时发作. 在67%的患者中存在自身抗体.
结论:
- SSc和LoS (形态) 的共存表明一个连续而不是不同的实体,由自身免疫和纤维化联系在一起.
- 建议监测具有风险因素的LoS患者,如雷诺现象或针对SSc进展的自身抗体.
- 共享的致病机制需要进一步研究这些类型的硬化皮肤病之间的相互作用.
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