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生物矿物化的微球触发了协同作用的calcicoptosis-ferroptosis,用于增强非小细胞肺癌治疗

Lingxiao Yang¹, Kaiyue Wang², Jia Dong³

¹Department of Respiratory and Critical Care Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000, China.

Acta biomaterialia

|October 3, 2025

概括

吸入式PCAL微球结合埃洛提尼布和阿尔特苏纳酸来诱导双细胞死亡途径,细胞和铁,有效治疗非小细胞肺癌 (NSCLC). 这种新的方法在临床前模型中显示出显著的瘤抑制,系统毒性最小.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

非小细胞肺癌 (NSCLC) 由于瘤异质性和耐药性而存在挑战.
传统疗法往往不能对抗复杂的NSCLC瘤.
诱导受调节的细胞死亡,如细胞和铁细胞,提供了一个有希望的替代策略.

研究的目的:

开发一种可吸入,对pH反应的药物输送系统 (PCAL微球) 用于NSCLC治疗.
利用双通道细胞死亡机制来克服治疗的局限性.
增强针对性交付和对NSCLC的协同有效性.

主要方法:

PCAL微球是用PLGA核心设计的,其中含有埃尔洛提尼布 (ERL) 和阿尔特苏纳酸 (ART),酸 (CaP) 和乳酸 (Lf) 功能.
该系统的设计是为了响应pH值,并积极准肺癌细胞.
在实验室和体内实验室进行了研究,以评估药物释放,细胞死亡诱导和小鼠模型中的抗瘤疗效.

主要成果:

PCAL微球显示了ELR和ART的受控释放,激活了calcicoptosis和ferroptosis通路.
ERL抑制了EGFR信号传递,而ART诱导了Ca2+过载和铁亡,由乳酸铁素向放大.
吸入PCAL显著抑制了肺癌小鼠模型中的瘤生长,具有良好的安全性.

结论:

雾化PCAL微球代表了NSCLC治疗的新有针对性的策略.
合成诱导和铁可提供增强的治疗疗效.
这种方法显示出克服耐药性和改善NSCLC患者治疗结果的潜力.

关键词:

生物矿物化生物矿物化石灰管化是指的发生.铁化是铁化的一种.非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.在PCAL微球上.

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