开发用于有效性试验的核心结果集,重点是婴儿和患有衰竭和营养的儿童
Allison I Daniel1, Kirrily de Polnay2, Michael McCaul3
1Consultant to the World Health Organization, Geneva, Switzerland adaniel@who.int.
BMJ global health
|October 3, 2025
概括
开发了六个核心结果集 (COS),以标准化关于儿童消耗和营养性的研究. 这些COS将提高未来关于预防和管理这些疾病的研究的质量和一致性.
科学领域:
- 公共卫生 公共卫生
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 世卫组织2023年指导方针的制定强调了在消耗和营养性的试验中具有多种结果的挑战.
- 确定需要标准化核心成果集 (COS),以改善证据综合和准则开发.
研究的目的:
- 开发六个有效性试验的COS,重点是预防和管理婴儿和儿童的消耗和营养.
- 为了与有效性试验 (COMET) 中的核心结果措施 (Core Outcome Measures in Effectiveness Trials) 的最佳实践方法保持一致.
主要方法:
- 采用了Delphi过程,该过程涉及指导方针开发小组和联合国儿童基金会/世卫组织技术咨询小组的专家.
- 采用利克特尺度 (1-9) 进行了两轮调查,通过特定的评分门来定义共识.
- 为了最终确定COS的结果,举行了多次共识会议.
主要成果:
- 通过德尔菲进程和共识会议,成功开发了6个COS.
- COS涵盖不同年龄组 (<6个月和6-59个月) 和不同环境 (住院,门诊/社区) 的消耗,营养性胀和体重不足.
- 专门的COS被创建用于严重的消耗,中度的消耗,以及预防消耗和营养性.
结论:
- 开发的COS将加强初级研究,未来的指导方针,以及关于儿童消耗和营养的决策.
- 这些COS确定了在未来的有效性试验中评估干预措施的关键结果.
- 预计这些COS的进一步开发和采用将加强该领域的研究.
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