内在的时间追踪器:时间上下文嵌入了体和海马的功能连接模式
Jingyi Wang1, Arielle Tambini2,3, Laura Pritschet1,4
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.
Nature communications
|October 3, 2025
概括
脑内皮层 (EC) 和海马体的休息状态大脑连接随着时间的推移自发地漂移,反映了时间的流逝. 这种缓慢的时间推移是独立于任务需求和其他因素.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 功能神经成像 功能神经成像
背景情况:
- 脑内皮层 (EC) 和海马体中任务唤起的神经活动跟踪时间上下文.
- 目前尚不清楚这些区域的自发神经信号是否也反映了时间的流逝.
研究的目的:
- 调查EC和海马体的静止状态连接模式是否表现出自发的时间漂移.
- 确定这些漂移是否反映了时间的流逝,而不依赖于任务需求.
主要方法:
- 密集采样休息状态fMRI数据来自两个个体超过30天.
- 在EC和海马体中分析全脑连接模式.
- 连接相似性和会话间的时间间隔之间的相关性分析.
主要成果:
- 在EC和前海马体的休息连接性相似性与会议之间的时间间隔负相关.
- 海马连接的漂移显示出前后梯度.
- 前侧EC表现出比后侧EC更强的时间漂移.
- 后脑网络驱动了EC和海马连接的漂移.
结论:
- 在休息状态的EC和海马连接中存在一种自发的,缓慢漂移的神经时间签名.
- 这种时间签名独立于任务需求和其他时间变化的因素.
- 在海马和EC的纵向轴上的功能梯度参与了追踪时间.
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