增强使用数字双胞胎的随机临床试验
Hossein Akbarialiabad1,2,3,4,5, Amirmohammad Pasdar6, Dédée F Murrell2,3
1University of Utah, Salt Lake City, UT, USA.
NPJ systems biology and applications
|October 3, 2025
概括
数字双胞胎 (DTs) 通过提高伦理和效率来增强临床试验. 这项技术提供了个性化医疗解决方案,但面临着实施挑战.
科学领域:
- 生物医学信息学是生物医学信息学.
- 临床试验方法论 临床试验方法论
- 个性化医疗是个性化的医疗.
背景情况:
- 随机临床试验 (RCT) 在道德标准和效率方面面临挑战.
- 数字双胞胎 (DTs) 提供了一种新的技术方法来解决这些局限性.
研究的目的:
- 探索数据技术在提高RCT内部的伦理标准方面的变革潜力.
- 研究DTs如何提高临床试验设计和执行的效率.
- 检查个人化医疗技术在个人化医疗连续的应用,从临床前到营销后.
主要方法:
- 在临床研究中对DT应用的文献综述和概念分析.
- 在个性化医疗工作流程中探索DT集成的探索.
- 识别和讨论DT实施的技术,法律和道德障碍.
主要成果:
- 数据技术可以显著改善RCT中的伦理考虑,包括患者安全,知情同意,公平和数据隐私.
- 通过早期检测不良事件和优化试验设计,DTs提高了试验效率.
- 从研究到市场监督,DT在个性化医疗治疗方面表现有前途.
结论:
- 数字双胞胎代表了临床试验和个性化医学的范式转变.
- 解决技术,法律和道德方面的挑战对于成功实施DT至关重要.
- 诊断技术有潜力通过实现更道德,更有效和更个性化的医疗干预来彻底改变医疗保健.
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