在一个种族多样化的儿童队伍中,对早发上腺衰竭的骨龄评估
Liya Kerem1, Marwa Tuffaha2, Aluma Chovel Sella3
1Division of Pediatric Endocrinology, Department of Pediatrics, Hadassah Hebrew University Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel. liya.em@gmail.com.
Pediatric research
|October 3, 2025
概括
患有过早上腺瘤的儿童的骨年龄的推进受到身体质量指数 (BMI),性别和种族/种族的影响. 这些因素需要个性化评估来准确评估增长.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 增长评估 增长评估
- 骨成熟的时间
背景情况:
- 骨龄 (BA) 评估对于评估儿童的生长和青春期发育至关重要.
- 在早产上腺症 (PA) 中经常观察到BA的进展,有时会促使进一步调查.
- 代谢和人口因素 (如BMI,性别,种族和种族) 对PA的BA进展的影响尚未完全理解.
研究的目的:
- 调查 BA 进展与儿童的 BMI,性别,种族和种族等因素之间的关联.
- 确定这些人口和代谢变量对这个队列的骨成熟的影响.
主要方法:
- 对296名被诊断患有单独的PA的儿童进行了回顾性图表审查.
- 对绝对和标准化BA进步的分析.
- 多变量线性回归模型根据年龄和其他共变量进行调整.
主要成果:
- 与正常体重儿童相比,肥胖儿童的BA进展显著更大.
- 男人表现出比女性更大的BA进步.
- 白人种族与较低的BA提升有关 (p=0.02).
- 体重指数,男性性别和西班牙裔种族是标准化BA进步的重要预测因素.
结论:
- 体重指数 (BMI),性别和种族/种族是PA儿童BA进展的重要决定因素.
- 这些发现强调了需要对PA的BA评估进行个性化解释的需要.
- 需要进一步的研究来探索BA在不同人群中的长期临床影响.
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