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Updated: Jan 16, 2026

ATAC-Seq Optimization for Cancer Epigenetics Research
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使用scTF-seqq剖析转录因子剂量对细胞重编程异质性的影响

Wangjie Liu1,2, Wouter Saelens1,2,3,4, Pernille Rainer1,2

  • 1Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Nature genetics
|October 3, 2025
PubMed
概括

我们开发了单细胞转录因子测序 (scTF-seq),以了解细胞重编程. 这种方法揭示了转录因子剂量如何影响细胞命运和异质性,推进基因调节和细胞工程.

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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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