一个具有高透性的新型费尔比纳克皮肤贴片:设计,开发和评估
1Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
AAPS PharmSciTech
|October 3, 2025
概括
这项研究开发了一种新的felbinac通过皮肤贴片,使用烯糖醇作为透增强剂. 新的贴片显著改善了felbinac的发放,并显示出有前途的稳定性和临床使用的安全性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 皮肤病学 皮肤病学
背景情况:
- 费尔比纳克是一种用于缓解疼痛的非类固醇抗炎药物 (NSAID).
- 通过皮肤递送药物比口服药物提供了优势,包括持续释放和减少全身副作用.
- 提高通过皮肤传递felbinac的效率对于改善治疗结果至关重要.
研究的目的:
- 设计和优化一种具有增强交付效率的新型费尔比纳克皮肤贴片.
- 评估开发的贴片的粘附性,体外释放性,稳定性和安全性.
- 评估通过新型贴片输送的费尔比纳克体内组织分布.
主要方法:
- 使用日历涂层方法制备了一种新的felbinac透皮贴片.
- 包括二醇 (PG) 在内的化学透增强剂被选,以优化通过皮肤递送.
- 实验室通过皮肤释放,粘附,稳定性 (4个月),皮肤刺激和体内组织分布的研究进行了.
主要成果:
- 1%PG的优化贴片在12小时内获得了189.03μg/cm2的累计皮肤透射量,是商业SELTOUCH®贴片的两倍.
- 透皮贴片表现出高粘附度,在4个月内稳定的透性,以及良好的安全性 (没有明显的皮肤刺激).
- 在体内研究显示,与商业产品相比,费尔比纳克在血,皮肤和肌肉组织中的度显著增加.
结论:
- 开发的费尔比纳克透皮贴片具有高粘附性,优越的透皮输送效率和出色的稳定性.
- 这种新型贴片代表了一种有前途的透皮药物输送系统,在疼痛管理中具有临床应用的巨大潜力.
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