和喉逆流:我们现在的情况. 一个系统的审查
Christos Tsilivigkos1, Konstantinos Papantoniou2, Evangelos N Vitkos3
1First Department of Otolaryngology, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, 15772, Greece. tsilivig@med.uoa.gr.
概括
酸盐在治疗喉回流 (LPR) 症状方面表现有前途,单独和与质子抑制剂 (PPI) 治疗. 建议进行进一步的大规模随机试验,以确认其在LPR管理中的有效性.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 喉喉逆流 (LPR) 涉及影响上空消化系统的胃内容.
- 酸盐经常用于管理LPR.
研究的目的:
- 系统地审查关于在LPR患者中使用阿尔金酸盐的文献.
- 评估阿尔金酸盐在LPR症状管理和并发性干眼综合征患者的疗效.
主要方法:
- 对 MEDLINE,Cochrane 和 Scopus 数据库进行符合 PRISMA 的系统审查.
- 包括以英语出版的研究,重点关注酸盐在LPR中的使用.
主要成果:
- 在134篇选的文章中,有16项研究符合纳入标准.
- 关键主题:临床医生对阿尔金酸盐的认识,阿尔金酸盐对LPR症状的影响,以及干眼LPR的影响.
- 临床研究涉及994人,评估症状缓解,耐受性和不良事件.
结论:
- 酸作为单一疗法和PPI的辅助疗法对LPR有益.
- 更大的随机研究是必要的,以巩固在LPR治疗中阿尔金酸的有效性.
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