用索拉芬尼布治疗的肝细胞癌患者的营养状况变化
Radosław Osmański1, Marcin Mardas2, Piotr Radomyski3,4
1Department of Oncology and Immuno-Oncology, Greater Poland Cancer Centre, Poznan, Poland.
在肝细胞癌 (HCC) 患者中,索拉菲尼布治疗期间脂肪和肌肉质量的损失显著恶化了无进展生存期 (PFS) 和整体生存期 (OS). 通过CT扫描评估的营养状况对于预测HCC结果至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 营养科学 营养科学
背景情况:
- 肌肉骨失衡在肝细胞癌 (HCC) 管理中经常被忽视.
- 它与HCC患者的不良结果有关.
- 营养状况评估对于预测存活率至关重要.
研究的目的:
- 用计算机断层扫描 (CT) 扫描来评估HCC患者的营养状况.
- 评估营养状况与无进展生存期 (PFS) 和整体生存期 (OS) 之间的关联.
- 分析索拉芬尼治疗期间的变化.
主要方法:
- 分析了接受全身治疗的122名HCC患者 (73名接受索拉芬尼布治疗).
- 通过CT扫描,体重指数 (BMI),预后营养指数 (PNI) 和营养风险评分 (NRS) 评估的营养状况 2002.
- 进行了生存分析,与CT衍生的脂肪和肌肉指数相关.
主要成果:
- 较低的PNI显著恶化了PFS和OS.
- 在患者中观察到生存的显著差异>10%的脂肪或肌肉质量损失.
- 皮下脂肪组织指数 (SATI),内脏脂肪组织指数 (VATI),骨肌肉指数 (SMI) 和psoas肌肉指数 (PMI) 的损失与较差的PFS和OS相关.
结论:
- 在接受索拉费尼布治疗的HCC患者中,脂肪和肌肉质量的损失与PFS和OS的恶化有关.
- 基于CT的身体成分评估是HCC中宝贵的预后工具.
- 在HCC治疗期间,监测营养状况至关重要.
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