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肠道微生物群和肺炎之间的因果关系:孟德尔的随机化和回顾性病例对照研究

Pengfei Huang¹, Yanqi Liu¹, Nana Li¹

¹Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang, 150001, China.

BMC pulmonary medicine

|October 3, 2025

概括

这项研究表明肠道微生物群和肺炎之间存在因果关系,发现阿克尔曼西亚属可能会降低重症监护肺炎患者死亡风险. 对肠肺轴的进一步研究是有必要的.

科学领域:

微生物组研究的研究.
肠肺轴肠肺轴肠肺轴
传染病流行病学传染病流行病学

背景情况:

人们已经认识到肠道微生物在肠肺轴上的作用,但其对肺炎的因果贡献尚不清楚.
之前的研究在实验和流行病学上探索了肠肺轴.
这项研究调查了肠道微生物群在肺炎发展中的潜在因果作用.

研究的目的:

调查肠道微生物群和肺炎之间的因果关系.
探索特定肠道细菌的潜在保护作用,如Akkermansia,对肺炎及其结果.
为未来的研究和临床应用提供关于肠肺轴的见解.

主要方法:

利用肠道微生物群全基因组关联研究 (GWAS) 和肺炎GWAS数据.
应用了门德尔随机化 (MR) 分析,使用逆方差加权 (IVW),加权中位数和MR-Egger方法.
采用了MR-PRESSO和MR-Egger的拦截系统来解决水平形.
进行了一项追溯病例控制研究,使用16S rRNA测序和PERMANOVA分析对来自重症肺炎患者的门拭子样本进行分析.

主要成果:

确定了肠道微生物群和肺炎 (重症监护) 和与肺炎相关的28天死亡率之间的潜在因果关系.
发现Akkermansia属和乳酸盐水平之间存在负相关性,并且在败血性ARDS患者中减少了ICU日.
在重症监护肺炎患者中观察到阿克尔曼西亚和28天死亡率之间存在潜在的负因果关系 (OR 0.42).

结论:

门德尔的随机分析支持肠道微生物群和肺炎之间的潜在因果关系.
阿克尔曼西亚属可能会降低重症监护肺炎患者28天死亡的风险.
阿克尔曼西亚也可能减少感染性ARDS患者的ICU天数和乳酸水平,提供对肠肺轴的见解.

关键词:

属阿克尔曼西亚属阿克尔曼西亚临床验证临床验证我们的肠道微生物群.门德尔的随机化分析.肺炎是一种肺炎.

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