相关实验视频

Updated: Jan 16, 2026

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

对前列腺组织运动诱导的表观遗传修饰的综述:对前列腺癌中基因表达和瘤进展的影响

Keng Ye¹, Zunjin Ke², Weima Gesang³

¹Hangzhou Linping District First People's Hospital, Hangzhou, 310000, Zhejiang, China.

Cancer cell international

|October 3, 2025

概括

定期体育活动可以通过影响荷尔蒙和表观遗传变化,如DNA甲基化,降低前列腺癌的风险. 运动在预防癌症和开发新的诊断工具方面表现有前途.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

流行病学研究将体育炼与降低前列腺癌 (PCa) 发病率联系起来.
运动会影响内源性激素 (胰岛素,,IGF) 和瘤微环境.
越来越多的证据表明,运动会诱导前列腺组织的表观遗传变化.

研究的目的:

审查前列腺组织中运动的分子机制.
探索运动对前列腺癌的治疗应用.
总结一下运动对PCa表观遗传修饰的影响.

主要方法:

关于身体炼和前列腺癌研究的文献综述.
分析分子途径,包括荷尔蒙和表观遗传变化.
检查运动对DNA甲基化,基因素修饰,miRNA和lncRNA的影响.

主要成果:

运动调节关键激素和瘤微环境.
运动与前列腺组织的表观遗传变化 (DNA甲基化,基因组修饰) 有关.
运动表现出抗癌性质,包括诱导亡和调节关键分子标记物.

结论:

运动会影响与前列腺癌发展和进展相关的分子通路.
运动诱导的表观遗传修饰具有预测性诊断和患者分层的潜力.
了解运动的分子效应可以为前列腺癌的治疗策略提供信息.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.通过DNA甲基化.表观遗传修饰表观遗传修饰表观遗传修饰运动运动运动.前列腺癌是什么意思前列腺癌是什么意思

更多相关视频

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...