加快衰老的变化以及心血管疾病和死亡率的风险:三个队列研究
Ji-Juan Zhang1, Han-Cheng Yu2, Ting-Ting Geng1,3
1Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
BMC medicine
|October 3, 2025
概括
加速衰老增加了心血管疾病 (CVD) 和死亡风险. 然而,从非加速衰老中恢复,延迟或维持衰老显著降低了这些风险,突出了衰老的动态性质.
科学领域:
- 老年学和老年病学 在老年学和老年病学.
- 心血管疾病流行病学
- 衰老的生物标志物
背景情况:
- 加速衰老是一个动态的过程,对其与心血管疾病 (CVD) 和死亡率的关联进行的研究有限.
- 这项研究研究了加速衰老的变化与大规模前性队列的健康结果之间的联系.
研究的目的:
- 评估加速衰老变化与心血管疾病和死亡风险之间的关联.
- 在中国和英国的三个不同的前景群体中分析这一关联.
主要方法:
- 利用了来自凯卢安 (n=107,830),东-通吉 (n=14,032) 和英国生物银行 (n=316,087) 队列的数据.
- 在基线和随访时使用PhenoAge和Klemera-Doubal方法 (KDM) 评估加速衰老的年龄.
- 采用考克斯的比例危险模型和元分析来确定危险比率 (HRs) 并总结发现.
主要成果:
- 基线加速衰老与心血管疾病和死亡风险增加显著相关 (PhenOAge:HR=1.41对于心血管疾病,HR=1.47对于死亡率).
- 参与者从加速衰老中恢复或延迟衰老,或保持非加速衰老,对心血管疾病和死亡率的风险显著降低.
- 当使用PhenoAge或KDM年龄进行评估时,结果是一致的.
结论:
- 加速衰老是心血管疾病和死亡率的重要危险因素.
- 干预措施或生活方式改变导致加速衰老的恢复或延迟,与改善的健康结果有关.
相关概念视频
01:30Coronary Artery Disease I: Introduction
878
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
878
01:26Aging
600
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
600
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
187
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
187
01:27Psychoneuroimmunology: Cardiovascular Disease
391
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
391
01:19The Effect of Aging on Tissues
3.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.3K
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K