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对于慢性炎症疾病和败血症的颗粒单细胞化

Toshiaki Iba1, Hideshi Okada2, Takahiro Miki3

  • 1Faculty of Medical Science, Juntendo University, 6-8-1 Hinode, Urayasu, Chiba, 279-0013, Japan. toshiiba@juntendo.ac.jp.

Journal of intensive care
|October 4, 2025
PubMed

粒细胞单核细胞吸附疗法（GMA）长期以来被用于治疗难治性慢性炎症性疾病。近期一项探索性临床研究显示，GMA对脓毒症具有疗效，并已获得日本批准使用。本综述旨在推广GMA在慢性与急性炎症中的相关知识。GMA是一种选择性体外治疗技术，旨在清除活化的粒细胞和单核细胞，这些细胞是多种免疫介导性疾病中炎症反应的关键驱动因素。GMA最初为治疗溃疡性结肠炎而开发，随后研究发现其在克罗恩病、类风湿关节炎及皮肤疾病等病症中亦具有免疫调节作用，机制涉及耗竭活化的髓系细胞并改变细胞因子谱，降低肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6水平，同时升高IL-10水平。GMA旨在不引起药物相关全身性免疫抑制的前提下恢复免疫稳态。近期，其应用已扩展至重症监护领域。在脓毒症及细胞因子风暴综合征中，由于先天免疫系统过度激活导致器官功能障碍，GMA可能提供治疗获益。在脓毒症患者的临床前模型及初步研究中，GMA显示出可减少炎症介质、改善血流动力学并促进器官功能恢复。基于上述潜力，GMA已于2025年8月在日本获批纳入保险报销范围，作为伴有全身炎症的脓毒症的辅助治疗手段。尽管GMA对特定患者群体具有前景，但目前支持证据仍有限，其疗效有待未来临床试验进一步验证。 粒细胞单核细胞吸附疗法，免疫调节，脓毒症，细胞因子风暴，炎症，体外治疗，髓系细胞，TNF-α，IL-6，IL-10

关键词:
细胞因子细胞因子颗粒细胞是颗粒细胞.血液过 血液过 血液过一个单细胞单细胞.性结肠炎是一种

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