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在 Beckwith-Wiedemann 综合征中高度可变的基因组甲基化与多位点印记干扰相关

Francesco Cecere1,2, Laura Pignata2, Emilia D'Angelo2

  • 1Institute of Genetics and Biophysics (IGB) "Adriano Buzzati-Traverso", Consiglio Nazionale Delle Ricerche (CNR), 80131, Naples, Italy.

Clinical epigenetics
|October 4, 2025
PubMed
概括

贝克威特-维德曼综合征 (BWS) 患者的多位印记障碍 (MLID) 与孕产妇效应基因变异和潜在的老化卵细胞有关. 这些干扰导致广泛的,可变的DNA甲基化变化,影响印制和非印制基因.

关键词:
通过DNA甲基化.基因组印记是指基因组的印记.打印障碍 打印障碍 打印障碍 打印障碍母亲影响基因.皮层下母体复合体 皮层下母体复合体

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