听力评估在输血依赖的β-thalassemia儿童在口服铁合剂的听力评估
Wafaa E I Mohamed1, Marwa Waheed Tolba2, Yara Khalid Abuelfadl1
1Pediatric Haematology Oncology and BMT Unit. Faculty of Medicine, Ain Shams University, Cairo, Egypt.
BMC pediatrics
|October 4, 2025
概括
这项研究发现,口服铁合剂在患有输血依赖β-血症的儿童中没有显著影响听力损失. 然而,开始输血的年龄与听力损失风险有关.
科学领域:
- 儿科血液学 儿科血液学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 临床听力学 临床听力学
背景情况:
- 众所周知,第一代铁化剂会导致β-血病患者的听力缺陷.
- 在这个人群中,第二代铁合剂的耳毒性风险仍然不清楚.
研究的目的:
- 为了评估患有输血依赖性β-thalassemia,接受口服铁化治疗的儿童的听力状况.
- 在这个群体中确定与听力障碍相关的风险因素.
主要方法:
- 一项涉及60名患有输血依赖β-血症的儿童和青少年的横截面研究.
- 综合的听力学评估,包括耳测量,纯音和语音听力测量,OAE (TEOAE和DPOAE).
主要成果:
- 16.6%的参与者表现出某种形式的听力损失,主要是轻微的高频感应神经或导电性听力损失.
- 听力障碍与性别,年龄,疾病持续时间或铁化剂治疗方案之间没有发现显著的关联.
- 在较年长的年龄开始输血和较低的血清费里水平与听力损伤有显著的关联.
结论:
- 口服铁化疗法对听力损失的频率或类型没有显著影响.
- 开始定期输血的年龄成为影响听力状况的关键因素.
- 建议在诊断时定期对beta-thalassemia患者进行听力查,然后定期进行.
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