用治愈意向治疗局部区域性复发性结肠癌 - 一个系统性审查
E Rademaker1,2, A Stapasolla Vargas Garcia2,3, I H J Sujecki1,2
1Department of Surgery, Isala, Zwolle, the Netherlands.
BMC surgery
|October 4, 2025
概括
结肠癌局部复发 (LRCC) 的治愈治疗可以产生高的生存率. 然而,关于LRCC患者选择和治疗策略的数据有限,这表明需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道瘤学 胃肠道瘤学
背景情况:
- 结肠癌局部复发 (LRCC) 是一个复杂的临床挑战.
- 虽然有可能接受治愈治疗,但最佳的患者选择和治疗策略仍然定义不佳.
- 对于与LRCC治疗意图干预相关的长期结果的了解有限.
研究的目的:
- 系统地审查有关LRCC故意治愈治疗的现有文献.
- 分析LRCC患者选择标准,治疗方法和相关的长期生存结果.
- 确定LRCC管理当前证据库中的知识空白和局限性.
主要方法:
- 从2010年到2024年8月,在多个数据库 (MEDLINE,Embase,Web of Science,Cochrane,Google Scholar) 中进行了全面的文献搜索.
- 包括专注于没有远程转移的单焦或多焦LRCC的研究,在初始结肠癌切除后以治疗意图进行治疗.
- 研究选择,数据提取和质量评估是由两个审查员根据PRISMA和MOOSE指南独立执行的.
主要成果:
- 包括54项研究,包括基于人口的系列,精选的队列和案例研究.
- 在基于人群的系列中,治愈治疗意图有所不同 (22%-81%),R0切除率为50%-75%,平均整体存活期为13-29个月.
- 一个由46名患者组成的综合病例系列显示了83%的R0切除率和86%的5年整体存活率,尽管这个群体容易产生偏见.
结论:
- 关于LRCC治疗和结果的文献很少,解释性和概括性有限.
- 对LRCC的治愈意图治疗可以在特定情况下实现高生存率.
- 在现有数据中存在显著的偏差风险,突出了需要更强大的研究的需要.
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