诊断和管理他类药物相关的肌肉症状
Jung-Joon Cha1, Soon Jun Hong2
1Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Korean circulation journal
|October 4, 2025
概括
类固醇相关的肌肉症状 (SAMS) 可以阻碍心血管疾病的预防. 本综述指导临床医生管理SAMS,优化他类药物治疗,并探索替代方案,以保持患者的坚持和降低风险.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 类他类药物相关的肌肉症状 (SAMS) 经常导致治疗不坚持,危及心血管风险降低.
- 准确的诊断对于将SAMS与肌痛的其他原因区分开来至关重要.
研究的目的:
- 审查SAMS的流行病学,病理生理学和临床表现.
- 概述基于证据的策略来管理SAMS和维持降脂疗法.
- 突出替代性降脂剂和组合疗法.
主要方法:
- 关于SAMS的综合文献综述.
- 对他类药物不耐受性的诊断标准的分析.
- 对替代性降脂疗法的临床试验数据的评估.
主要成果:
- 与中度强度的他类药物和埃泽胺的联合治疗在高危患者中显示出有效性和耐受性.
- 像PCSK9抑制剂和bempedoic酸这样的替代药物为管理SAMS提供了选择.
- 一种以患者为中心的方法改善了坚持和心血管风险管理.
结论:
- 对SAMS的有效管理对于持续的他类药物治疗和心血管保护至关重要.
- 个性化治疗策略,包括替代药物和组合疗法,是关键.
- 优化降脂疗法的坚持,最大限度地减少不良事件,降低心血管风险.
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