在患有糖尿病前期的成年人中,sarcopenia和2型糖尿病之间的关系:来自前性队列研究的证据
Yingxin Liu1, Zemin Li1, Ruoting Wang1
1Center for Clinical Epidemiology and Methodology (CCEM), The Affiliated Guangdong Second Provincial General Hospital of Jinan University, 466 Newport Middle Road, Haizhu District, Guangzhou, 510317, Guangdong Province, China.
Diabetology & metabolic syndrome
|October 4, 2025
概括
肉症是一种肌肉损失的情况,在糖尿病前期患者中显著增加患2型糖尿病 (T2DM) 的风险. 保持肌肉健康可能有助于预防T2DM的进展.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 由于研究结果不一致,在糖尿病前期患者中,sarcopenia和2型糖尿病 (T2DM) 之间的联系仍然不清楚.
- 这项研究旨在澄清萨科佩尼亚与成年人从糖尿病前期发展为T2DM之间的关联.
研究的目的:
- 调查萨科佩尼亚和T2DM发病率在被诊断为糖尿病前期的成年人之间的关系.
- 确定萨科佩尼亚是否是该人群T2DM发展的独立风险因素.
主要方法:
- 利用了来自英国生物银行队列的数据,包括基线糖尿病前期参与者.
- 使用2019年EWGSOP2标准 (手握强度,肌肉质量,步行节奏) 评估了sarcopenia.
- 采用多变量考克斯回归分析来评估肉类和T2DM事件之间的关联,并根据各种共同变量进行调整.
主要成果:
- 包括60325名患有糖尿病前期的参与者;7139人 (11.8%) 患有肉症.
- 在11.4年的随访期间,9305人 (15.4%) 患有T2DM.
- 皮症与T2DM风险增加22%有关 (HR=1.22,95% CI:1.15-1.30),特别是在腰部和部比率<0.9.9的患者中.
结论:
- 肉症与患有糖尿病前期的成年人患T2DM的风险增加有显著的关联.
- 肉类可能成为T2DM的关键风险标志物.
- 专注于维护和改善肌肉健康的干预措施可能是减缓糖尿病前期进展到T2DM的新策略.
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