根据ARIA分类对中度至重持续性AR表型的明显临床和细胞因子特征:COCOA
Da Kyeong Lee1, Jisun Yoon1, Hyo-Won Lee2
1Department of Pediatrics, Childhood Respiratory and Allergy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Allergy, asthma & immunology research
|October 4, 2025
概括
一项研究发现,4.4%的韩国儿童患有中度至重度过敏性鼻炎 (AR). 早期过敏原敏感化和产前抗生素使用是这种AR表型的关键风险因素.
科学领域:
- 儿科过敏和免疫学
- 环境流行病学环境流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 全球过敏性鼻炎 (AR) 的患病率正在上升.
- 了解不同的AR表型对于有效管理至关重要.
- 在一般儿科患者中AR表型需要进一步探索.
研究的目的:
- 在韩国儿童中使用过敏性鼻炎及其对喘影响 (ARIA) 分类来识别明显的过敏性鼻炎 (AR) 现型.
- 调查小儿科队列中中度至重度持久性AR表型的流行率.
- 探索与AR表型相关的风险因素和免疫标记.
主要方法:
- 研究了一组1113名7岁以上的韩国儿童.
- 使用了AR和ARIA分类的医生诊断.
- 皮肤刺伤测试和细胞因子测试 (IL-4,IL-5,IL-17A) 在3岁和7岁时进行.
主要成果:
- 7岁时AR的患病率为48.9%,其中4.4%呈现中度至重度的持久表型.
- 剖腹产与轻度间歇性AR相关;产前抗生素使用与中度至重度持续性AR相关.
- 对特定过敏原的早期敏感 (3岁) 和晚期敏感 (7岁) 增加了严重AR表型的风险. 在严重表型组中观察到3岁时IL-4和7岁时IL-5/IL-17A的升高.
结论:
- 根据ARIA标准,大约4.4%的韩国儿童呈现中度至重度的持续性AR表型.
- 产前接触抗生素和早期对常见过敏原的敏感性是显著的危险因素.
- 中度至严重的持久性AR表型涉及T助手2和T助手17免疫反应,表明复杂的炎症模式.
相关概念视频
Asthma-II: Pathophysiology and Classification
4.1K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma-III: Symptoms and Complications
3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.3K
Asthma: Pathogenesis and Management
1.2K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Allergic Reactions
32.0K
Overview
32.0K


