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在动物中建模脑.

Katharina A Quinlan1,2, Emily J Reedich1,2, Elvia Mena Avila1,2

  • 1University of Rhode Island, College of Pharmacy, Kingston, RI, USA.

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科学领域:

  • 神经科学是一个神经科学.
  • 翻译医学是一种翻译医学.
  • 动物模型 动物模型

背景情况:

  • 大脑 (CP) 治疗的进展在很大程度上依赖于动物研究.
  • 目前的动物模型往往缺乏使用临床相关措施对性和 dystonia 的全面评估.
  • 感官差异和疼痛是人类CP的关键方面,很少在动物模型中进行研究.

研究的目的:

  • 根据获得的神经系统损伤,审查和比较CP的临床前模型.
  • 突出在PC动物研究中需要标准化,临床相关的结果测量.
  • 鼓励动物模型中对感官和运动系统进行可靠的评估.

主要方法:

  • 随着时间的推移,在脑研究中使用的临床前模型的总结.
  • 在常见的实验室动物物种中比较发育时间表.
  • 对动物模型中运动和感觉功能的现有测量技术的分析.

主要成果:

  • 大多数现有的CP动物模型尚未通过临床相关措施得到充分验证.
  • 在PC研究中使用的动物物种,伤害类型和结果措施中存在显著的多样性.
  • 将人类临床测量转化为可靠的动物评估提出了相当大的挑战.

结论:

  • 在CP动物模型中,对于评估感觉和运动系统的标准化,可靠和可重复的测量非常需要.
  • 一致的方法将提高动物研究结果的可转化到人类CP治疗的可能性.
  • 采用共同的数据元素和验证的措施对于推进CP研究至关重要.