抗新血管性纳米输送系统:基于瘤和眼科疾病的研究进展
Bingjie Guo1, Zhaokai Li1, Junyi Zhou1
1Inner Mongolia Medical University, No. 5, Xinhua Road, Hohhot, Inner Mongolia 010059, China. 17771564957@163.com.
Journal of materials chemistry. B
|October 4, 2025
概括
纳米药物输送系统通过克服传统药物的局限性,为瘤和眼睛疾病提供了改进的抗血管生成疗法. 这些系统可提高药物输送的精度和药物的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 异常的新血管化是癌症和眼部疾病等疾病的核心.
- 抗血管性药物是关键疗法,但具有包括毒性和耐药性在内的局限性.
- 纳米药物输送系统对抗血管生成疗法具有优势.
研究的目的:
- 审查用于抗血管生成疗法的纳米药物输送系统的进展.
- 总结瘤和眼科疾病中的机制,传递策略和应用.
- 讨论功能化和组合纳米疗法用于抗血管生成.
主要方法:
- 关于纳米药物输送系统的最新研究的文献综述.
- 分析纳米载体策略,以准确和持续释放药物.
- 专注于功能化和组合纳米药物方法.
主要成果:
- 纳米药物系统在克服传统抗血管生成药物的局限性方面表现有前途.
- 有针对性的分娩和持续释放可以改善治疗结果.
- 功能化和组合纳米疗法提供了增强的抗血管生成潜力.
结论:
- 纳米药物输送系统在治疗新血管化相关疾病方面取得了重大进展.
- 对功能化和组合纳米疗法的进一步研究是有必要的.
- 应对挑战将优化纳米医学用于抗血管生成应用.
相关概念视频
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Ophthalmic Drug Delivery Systems
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...


