术前心房并没有影响左心室辅助器件接受者的长期生存和并发症
Miloud Cherbi1, Vincent Galand2, Valentin Barré3
1Cardiology Department, Toulouse University Hospital, Toulouse, France.
Artificial organs
|October 4, 2025
概括
在接受左心室辅助器件 (LVAD) 的患者中,先前存在的心房动 (AF) 并没有增加死亡率或中风风险. 然而,AF与晚期心室节律失常 (VAs) 的更高发病率有关.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 临床研究 临床研究
背景情况:
- 在接受左心室辅助器件 (LVAD) 的患者中,心房动 (AF) 是常见的.
- 在LVAD植入后,AF对生存和心室节律失常 (VAs) 等结果的影响尚不清楚.
研究的目的:
- 在接受左心室辅助器件 (LVAD) 植入的患者中调查先前存在的心房 (AF) 的预后意义.
- 评估AF和死亡率之间的关联,以及包括VA在内的特定不良事件.
主要方法:
- 来自多中心ASSIST-ICD观察研究中的患者的倾向得分匹配分析.
- 评估所有原因死亡率,心血管和非心脏死亡率,出血,中风,血栓,以及早期/晚期VA.
主要成果:
- 在652名LVAD接受者中,43.9%的患者有先前存在的AF.
- 在匹配后,AF与死亡率增加 (HR 0.93 [0.69-1.26]) 或其他不良事件无关,除了晚期VA的发病率更高.
结论:
- 在LVAD患者中,先前存在的AF与较高的死亡率,出血,中风或血栓形成无关.
- 在LVAD植入后,AF与晚期心室失常症 (VAs) 的风险增加有关.
- 早期设备的发现需要谨慎地解释,如HeartMate 3等新设备;需要进一步的研究.
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