Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

677
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
677
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

150
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
150
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

253
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
253
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

406
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
406
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

166
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
166
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

225
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
225

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Treatment Patterns and Experienced Effects of Semaglutide for Weight Management Among Adult Users in Denmark: A Community Pharmacy-Based Cross-Sectional Survey.

Diabetes, obesity & metabolism·2026
Same author

Making Transparency and Reproducibility a Hallmark of Nordic Real-World Evidence.

Basic & clinical pharmacology & toxicology·2026
Same author

Use of Glucagon-Like Peptide-1 Receptor Agonists in Danish Adolescents and Young Adults 2018-2025.

Obesity (Silver Spring, Md.)·2026
Same author

Medication Exposure Definitions in Perinatal Pharmacoepidemiology: Implications for Pregnancy Studies.

Paediatric and perinatal epidemiology·2026
Same author

Time Windows Used When Identifying Current Drug Use and Polypharmacy.

Pharmacoepidemiology and drug safety·2026
Same author

Strategies to Enhance Satisfaction and Success in an Academic Career in Pharmacoepidemiology.

Pharmacoepidemiology and drug safety·2026

相关实验视频

Updated: Jan 16, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

在药物流行病学分析中为"处方者类型"进行调整

Saad Hanif Abbasi1, Jesper Hallas1, Peter Bjødstrup Jensen1

  • 1Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Basic & clinical pharmacology & toxicology
|October 4, 2025
PubMed
概括

在药物流行病学研究中,根据处方者类型进行调整是有价值的. 对直接口服抗凝剂 (DOAC) 与华法林的分析发现,处方者类型是效果修饰剂,影响中风风险发现.

关键词:
混者调整 混者调整混是一种混.药学流行病学 药学流行病学处方者设定了处方者的设置.处方者类型 处方者类型

更多相关视频

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

相关实验视频

Last Updated: Jan 16, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.0K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

科学领域:

  • 药理流行病学 药理流行病学
  • 医疗保健服务研究 医疗服务研究
  • 生物统计学 生物统计学

背景情况:

  • 处方者类型往往是制药流行病学研究中的混因素,影响治疗暴露和患者的结果.
  • 医疗保健注册表经常包含处方者类型数据,但在分析中未得到充分利用.
  • 了解处方者的影响对于准确的药物安全评估至关重要.

研究的目的:

  • 调查调整处方者类型在药物流行病学研究中的价值.
  • 评估处方者类型对直接口服抗凝剂 (DOAC) 与缺血性中风风险之间的关联的影响.
  • 为了确定处方者类型是否在这种关联中起到作用的作用.

主要方法:

  • 一项使用丹麦医疗保健登记册的队列研究.
  • 直接口服抗凝剂 (DOAC) 和华法林之间缺血性中风风险的比较.
  • 根据年龄,性别和处方者类型进行统计调整;进行了相互作用测试和分层分析.

主要成果:

  • 初步分析 (年龄,性别调整) 显示,DOAC与华法林的危险比率 (HR) 为0.95 (95% CI:0.90-1.01).
  • 根据处方者类型的进一步调整,类似的HR为0.92 (95%CI:0.87-0.98).
  • 处方药类型通过相互作用测试和分层分析被证实是显著的效果修饰剂.

结论:

  • 根据处方者类型进行调整可以完善药理流行病学发现.
  • 处方药类型显著改变了DOAC和缺血性中风风险之间的观察到的关联.
  • 需要进一步的研究来探索处方者类型调整在不同临床环境中的作用.