最近的进步,从天然的石类物质中发现了潜在的抗瘤剂
Xingrui He1, Rui Fan1, Mengting Liu1
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
概括
植物衍生性基胺通过诱导癌细胞死亡和抑制关键途径,显示出有前途的抗瘤作用. 为了临床应用,需要进一步的研究和药物输送系统.
科学领域:
- 植物化学和药理学
- 自然产品化学 自然产品化学
- 癌症生物学 癌症生物学
背景情况:
- 多种植物代谢物塞斯基特类,对癌细胞具有显著的细胞毒性作用.
- 它们的结构复杂性和生物活动为开发新型抗癌药物提供了机会.
- 对最近的进展进行全面的审查对于了解其治疗潜力至关重要.
研究的目的:
- 审查石类药物的抗瘤作用和治疗应用.
- 为了阐明信号通路和蛋白质参与sésquiterpenoid介导的抗癌机制.
- 为突出2020-2024年的研究,并指导未来的临床翻译.
主要方法:
- 从2020年起对Web of Science和PubMed进行系统的文献搜索.
- 关键词包括"抗瘤"",六烯"",机制"和"信号通路".
- 描述了112种天然的甲和它们的作用机制.
主要成果:
- 塞斯基特类药物通过反应性氧物种 (ROS) 的过度生产,表现出抗瘤活性.
- 观察到关键信号通路的抑制,例如PI3K/Akt,NF-κB和STAT3.
- 与亡相关的蛋白质的调节,包括caspase-3和BAX的上调和BCl-2的下调,增强了编程细胞死亡.
结论:
- 塞斯基特类药物表现出抗瘤活性,毒性较低,副作用较常规药物少.
- 它们的临床实用性目前仅限于辅助作用,因为它们的疗效较弱,药物动力学挑战较大,例如溶解性和生物可用性较差.
- 结构改造和先进的纳米颗粒传递系统是增强塞斯基特类有效性和临床转换的有希望的策略.
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