摄入量和胃癌风险:观察性研究的系统审查和剂量反应元分析

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Alex Richard Costa Silva¹, Marcela de Araújo Fagundes², Valdete Regina Guandalini³

¹Graduate Program of A.C.Camargo Cancer Center, São Paulo, Brazil.

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概括

更高的摄入量可能会降低胃癌 (GC) 的风险. 一项元分析发现,每增加300毫克/天,风险降低10%,这表明.

科学领域:

营养与癌症流行病学
胃肠病学研究胃肠病学研究
饮食公共卫生饮食公共卫生

背景情况:

摄入量已被用于癌症预防,但对于胃癌 (GC) 的证据仍然不一致.
之前的研究表明,摄入量与GC风险之间存在不同的关联.
了解的作用对于开发有效的GC饮食预防策略至关重要.

研究的目的:

进行一项元分析,评估饮食摄入量与胃癌风险之间的关联.
探索剂量反应关系,以确定保护作用的潜在值.
综合来自对和GC的队列和病例控制研究的证据.

主要方法:

在主要数据库 (PubMed,Scopus,EMBASE,LILACS,Web of Science) 进行全面的文献搜索,截至2024年8月19日.
包括13个队列和病例控制研究,共计1,610,992名参与者;通过纽卡斯尔-太华规模评估质量.
随机效应模型对相对风险 (RRs) 的元分析,用剂量反应和非线性分析.

主要成果:

一个分类比较 (最高与最低摄入量) 显示了一个非显著的反向关联 (RR:0.85;95% CI:0.70-1.05).
剂量反应分析显示了显著的线性保护作用:10%的GC风险降低每300毫克/天增加饮食 (RR:0.90;95%CI:0.82-0.99).
非线性分析表明,在400毫克/天以上,风险降低更明显 (p < 0.001).

结论:

饮食中摄入较高的与胃癌风险降低有关.
剂量反应关系表明有保护作用,特别是在摄入量超过400毫克/天时.
饮食中的可能在GC预防中发挥作用,这需要进一步调查和考虑公共卫生建议.

关键词:

摄入的摄入量补充剂补充剂饮食中的是.胃癌是什么?胃癌是什么?胃癌是一种胃癌.

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